About NCI – Organic Aged Black Garlic (ABG)
Recogen® For Sportsperson
About Bone and Joint health
About Bone K+
About BrainFit - Supplement for Smarter Kids
Garlic has been used worldwide as both a food ingredient and medicine for over 4000 years to treat several disorders such as arthritis, diabetes and infectious diseases (common cold, malaria and tuberculosis).
Whole garlic contains a compound called alliin. When garlic is crushed or chewed, this compound turns into allicin, the main active ingredient in garlic.
However, allicin is unstable and is not effectively absorb into the body unless it is broken down into compounds the body can use. NCI Organic ABG extract uses a proprietary patented process to convert the highly odorous and unstable compounds in fresh garlic into less odorous and more stable bioactive compounds such as S-Allyl Cysteine (SAC).
SAC, a stable & potent antioxidant, is water-soluble with higher bioavailability resulting in excellent absorption compared to raw garlic.
NCI ABG is:
Many studies have shown that eating garlic can provide a wide variety of health benefits. This includes reduced heart disease risk, improved mental health and enhanced immune function, inhibits bacteria growth, lowers cholesterol and blood pressure. Studies have proven that ABG has higher amounts of antioxidants and biological activity than regular garlic. Antioxidants are known for reducing harmful free radicals in the body. It is particularly protective against the common cold and the flu.
Garlic Can Boost Immune Function
Garlic contains compounds that help the immune system fight germs. It has shown to boost the disease-fighting response to some types of white blood cells in the body when they encounter viruses, such as common cold or flu virus.
Garlic has shown promising results for preventing colds and the flu. Several studies have shown that garlic reduces the risk of becoming sick in the first place, as well as how long you stay sick. It can also reduce the severity of symptoms.
Garlic is effective in preventing common colds and flu. This study gave 146 healthy volunteers either garlic supplements or a placebo for three months. The garlic group had a 63% lower risk of getting a cold, and their colds were also 70% shorter. They are less likely to be re-infected by almost 7 times.
Adv Ther. 2001 Jul-Aug;18(4):189-93. Preventing the common cold with a garlic supplement: a double-blind, placebo-controlled survey. Josling P1.
Study: Preventing the common cold with a garlic supplement: a double-blind, placebo-controlled survey.
Participants: 146, 63/grp (matched sex, age & garlic consumption)
Objectives: Determine the effect of consuming 2.56 g AGE daily.
Duration: 90d, November and February
Test results: End of Feb, 90d
They used a five-point scale to assess their health and recorded any common cold infections and symptoms in a daily diary. (5 = well, no problems; 4 = quite well with occasional sneeze, not disruptive to normal routine; 3 = can feel a cold coming on, some minor symptoms; 2 = feeling low and beginning to exhibit symptoms; 1 = full cold symptoms [headache, sneezing, runny nose, tiredness]). If a cold occurred, volunteers noted the number and variety of symptoms, the day recovery began, and the day they felt completely better.
1. Fewer colds reported in the treatment group:
Treatment group (TG): 24 people
Placebo group PG: 65 people (P < .001).
2. Faster recovery in TG:
TG: 4.63 days
PG: 5.63 days
3. Shorter duration of symptoms (P < .001).
TG: 1.52 days
PG: 5.01 days
4. Shorter no. of days with a cold
TG: 2.6 days
PG: 6.38 days
5. Less likely to have re-infection (experience more than 1 full-blown cold)
TG: 2 people
PG: 16 people
Volunteers in the treatment group were less likely to get a cold and recovered faster if infected. The garlic group had a 63% lower risk of getting a cold, and their colds were also 70% shorter. Volunteers taking placebo were about 7x more likely to have more than one cold over the 3 months period.
The study demonstrated accelerated relief, reduction in the severity of troublesome symptoms such as sneezing, cough and runny nose, and recovery to full fitness. A reduced likelihood of becoming re-infected with other viral strains indicated general improvement in the immune system with the garlic supplement.
Black garlic reduces severity in common cold and flu. This study found that colds were on average 61% shorter for subjects who ate aged garlic extract compared to a placebo group. Their colds were also less severe.
Title: Aged Garlic Extract Modifies Human Immunity
Participants: 120 healthy individuals, 60 for each group, 21 and 50 y of age, the average age was 26 y and 60% were female
Objectives: Determine the effect of consuming 2.56 g AGE daily.
Duration: 90 days
Test results for blood drawn:
1. 0 d,
2. 45 d to determine if immune changes had occurred.
3. 90 d to capture the full cold and flu season.
After 90 d of AGE/placebo supplementation, the diaries were collected were analyzed. With 55% of the placebo group and 45% of the AGE group reporting illnesses, no significant difference in the incidence of colds and flu was seen between the groups (Figure 2A). Participants who consumed AGE appeared to have a reduction in the severity of their illness, as noted by a reduction in the number of symptoms reported (Figure 2B), and a reduction in the number of days they functioned sub-optimally and/or missed work or school due to illness (Figure 2C). These results suggest that, although not helping to prevent an illness, the addition of AGE to the diet could be useful in reducing illness severity.
After 90 d, although the number of illnesses was not significantly different, the AGE group showed reduced cold and flu severity, with a reduction in the number of symptoms, the number of days participants functioned sub-optimally, and the number of work/school days missed. These results suggest that AGE supplementation may enhance immune cell function and may be partly responsible for the reduced severity of colds and flu reported. The results also suggest that the immune system functions well with AGE supplementation, perhaps with less accompanying inflammation.
Source: J Nutr. 2016 Feb;146(2):433S-436S. doi: 10.3945/jn.115.210427. Epub 2016 Jan 13.
View the difference between different types of garlic & NCI’s aged black garlic here
Recommend Age: Above 6 years old
Disclaimer: Results vary across individuals. We highly recommend you to consult a healthcare professional prior to taking if you are on any medication.
Please view the comparison chart here
Recogen® is a made in Germany 100% Bioactive Collagen Peptides (BCP) food supplement. Recogen® is pure protein and contains high concentrations of important joint building blocks, such as glycine and proline.
BCP is obtained by means of enzymatic hydrolysis of collagen-containing tissue from the bovine hides of healthy animals to help facilitate its absorption into the blood stream.The amino acid composition in BCP is similar to collagen and therefore helps to stimulate cartilage regeneration.
BCP is also an effective supplement that helps to nourish body tissues, cartilages, bones, tendons, ligaments, hair, nails and skin.
Recogen® is a premium brand developed and conceptualized by NCI.
Recogen® is available in the following type:
Our joints undergo a tremendous amount of stress over its lifetime. The stress placed on our joints means that they are prone to damage in the longer term as cartilage is worn out and sometimes even lost.
Recogen® contains the key ingredient, Bioactive Collagen Peptides, for joint care supplements. Recogen® has 3 unique advantages that separate it from other products:
2. Short peptide chains = Excellent absorption by body to reach targetted areas
The absorption rate of Recogen® by the body is enhanced as the long peptide chains of normal collagen are broken down via enzymatic hydrolysis into very short chains.
3. Extensive scientific reports spanning over 30 years
The beneficial effect of Bioactive Collagen Peptides on joint health was first discovered in the 12th century, between 1098 to 1179 when Saint Hildegard of Bingen first described the beneficial effect of calf cartilage broth on joint pain. Since then there have been numerous scientific reports spanning over 30 years describing the beneficial effects of Bioactive Collagen Peptides.
Recogen®'s effectiveness is based on the following factors:
1) Absorption rate and accumulation levels
Recogen® has a short peptide chain with extremely low molecular protein peptides content (approx. 3,000 daltons). With its excellent solubility, it is easily digested and absorbed into your body to increase the bioavailability of Type 2 collagen.
2) Stimulation of Type 2 Collagen and proteoglycans production
Due to Recogen's Bioactive Collagen Peptide specific function, it helps to stimulate the production of type 2 collagen and proteoglycans. Type 2 collagen and proteoglycans form 90-95% of cartilage tissue. By increasing the production of type 2 collagen and proteoglycans, cartilage can regrow.
3) Reproduction of supportive joint tissue
Research indicates that Bioactive Collagen Peptide is not only readily and rapidly absorbed into the body system but also reaches the targeted joint tissue. In the presence of Recogen's Bioactive Collagen Peptides , the collagen production and regeneration of supportive tissue were both stimulated. This creates a positive change in the targeted joints.
MRI images that shows how consumption of Recogen® helps boost cartilage growth.
Recogen® is an ideal health supplement for everyone who want to stay active and well-being. Individual who wishes to reduce their risk of degenerative joint disease should take Recogen® as constitutional nutrition.
Recogen® will benefit:
1) BSE Free. Not genetically modified
Recogen® is a food, NOT a drug. Recogen® contains 100% pure Bioactive Collagen Peptides (BCP) that is not genetically modified and free from Bovine Spongiform Encephalopathy (BSE,which causes Mad Cow Disease).
Every batch of Recogen® comes with a Veterinary Certification to certify it as BSE free. Recogen® does not contain any other additives and preservatives.
2) No Side Effects. Strong clinical evidence
Recogen® has NO SIDE EFFECTS. Recogen® is perfectly safe for long-term regular consumption and it's effectiveness in cartilage regeneration is backed by more than 20 years of clinical research.
3) Awarded GRAS status by U.S FDA
BCP was awarded GRAS (Generally Recognized As Safe) status by the U.S Food and Drug Administration (FDA) in 1999. BCP is recognized as a food additive in the EU and is still pending for status approval in Japan.
4) Recognized by WHO
The "Bone and Joint Decade" was initiated by the World Health Organization (WHO) and the United Nations (UN) in order to improve the overall care and treatment of patients suffering from bone and joint diseases.
As BCP has particular benefits for joint health, it is a key focus of this inititative. For further information, you may visit www.boneandjointdecade.org.
5) HALAL Certification
Recogen® is certified HALAL by MUIS Singapore and therefore safe for consumption amongst our Muslim consumers.
It is also interesting to compare the absolute amounts of amino acids in BCP and other protein-rich food. Based on grams of amino acid per 100g of BCP and food respectively the following ratios have bee established See graph on amino acid content below.
The table shows to obtain the same amount of glycine in 10g of Recogen®, you will need to take:
2.9L of milk or
164 g of pork
For the same amount of proline, you will need:
1.2kg of potatoes
140g of wheat bread
This comparison confirms that BCP provides the required amounts of the most important amino acids for the cartilage metabolism much more effectively and more selectively than any other protein containing food.
Extremely low molecular weight
BCP has an extremely low molecular weight of 3 to 6 kDaltons. Compared to normal gelatine with a molecular weight of around 100 kdaltons, it is easily absorbed into the blood stream
Recogen® and its biological Value
It is confirmed that Recogen® differs in its amino acid composition from other natural protein rich food. The graph below shows a comparison between Recogen® and the average occurrence of amino acid in natural protein-rich food. The natural protein-rich food refers to gelatine, milk Meat, potato, bread etc. The biggest differences are in glycine and proline; in BCP, these are 3 times as high as in other proteins.
However, it is not only the percentages but also the absolute amounts of amino acids in gelatine and other protein-rich food that are interesting and stand much in favor for BCP. Based on grams of amino acid per 10g of Recogen® and food respectively, the following ratios have been established as below.
The table shows that the consumption of About 2.8L of milk or 1.8kg of potatoes would be required to take in the same amount of glycine that is contained in 10g of Recogen®. The proline content in 10g of Recogen® is equivalent to 110g of meat, 1.2kg of potatoes or 140g of wheat bread.
Moreover Hydroxyproline which is particularly important for the selective collagen synthesis can only be detected in substaincial amounts in Recogen®.
The amino acid content in different food (1g amino acid per 100g food)
Latest osteoarthritis research findings: Objective visual evidence that Recogen® promotes the regeneration of cartilage tissue.
This has been confirmed by the results of two independent investigations which were presented in September 2009 at the congress of the Osteoarthritis Research Society International (OARSI) in Montreal.
A clinical trial performed by Harvard Medical School and Tufts Medical Center demonstrated the efficacy of Recogen® on the basis of magnetic resonance images (MRI). Working in collaboration with Kiel University, scientists at the Kiel-based Collagen Research Institute (CRI) then gathered experimental evidence of the effects of consumption of Recogen® on cartilage cells.
Using an objective imaging technique, the Tufts researchers, led by Dr Timothy McAlindon, found a significant regeneration of the cartilage tissue in the Recogen® group, compared to normal cartilage degeneration progression in the placebo group. The CRI’s cell experiments indicated that Recogen® induces the increased synthesis of aggrecan (an important component in cartilage) and Type II collagen (which plays a key role in cartilage elasticity).
The role of Recogen® in the treatment and prevention of osteoarthritis
The administration of Recogen® can prevent joint degeneration and counteract load-induced wear of the articular cartilage. Compared to other substances which focus on providing short-term pain relief, Recogen® tackles the root causes of osteoarthritis and cartilage degeneration. Previous clinical trials had already shown that the substance promotes mobility and reduces pain.
Classified as a safe nutritional product by the FDA, Recogen® is easy to synthesize. Furthermore, thanks to its neutral taste and odour, Recogen® can be easily added to the individual’s daily diet. Positive health effects can be achieved even with low doses. Recogen® is suitable for all age groups with particular benefit for athletes (competitive and amateur), elderly persons and all health-conscious individuals who want to prevent cartilage degeneration at an early stage.
Study Objective: Testing for efficacy, tolerability / acceptance / adverse effects and fast pain relief. Study was conducted at Regio Kliniken, Germany in 2010.
Study design: Daily oral application of 5.5g of Recogen® Gold over 12 weeks
Measurements: WOMAC scores - pain, stiffness, activities and composite (total scores)
Results: Clinical data showed a clear improvement in more than 75% of subjects after a 12 weeks Recogen® Gold therapy. Subjects have shown improved mobility as well as reduction in pain during activity and at rest.
Click on link to view actual written testimonials. We may edit or translate the actual testimonials to make it convenient for you to read. Please note a new window will pop up when you click on the link.
2014 - 2016 TESTIMONIALS
Mr Ron Wang, 29 years old (English text) - " I suffered knee pain when doing long distance run. For this reason, I'm not able to run for long distance for years. After consuming Recogen®, I tried longer distance run and my knee problem was solved like over night. I'm confident in the product and is back to purchase
Mdm Mary Lim Siew Noy, 71 years old (Chinese text) - " I injured my right arm after a fall. My friend recommended me Recogen® Gold. After consuming for a month, I went for a follow up with my doctor and my doctor told me I recovered very well. Now, I'm recommending Recogen® to my friends!"
Ler Noi Hiang, 67 years old (Chinese text) - " I was recommended to Recogen® by my friends. I've been trying painkillers and other supplements early on. Then I tried Recogen® Gold for a month and my knee pain has subsided.
Nelson Ong, 54 years old (English text), " I have fingers joint problem and within seven days only, the pain is gone. Recommended to wife and friends and feedbacks were good! Thank you!"
Mdm Lew Poo Chu, 57 years old (Chinese text)- " I've suffered from joints pain for a while already. A friend recommended Recogen® to me and I tried it for a week. After a week, my joint pains symptoms have improved."
Mdm Yap Siew Hua, 54 years old (Chinese text), "I'm suffering from pain in my neck for several months already. My friend gave me a can of Recogen® Gold and I tried it for a week. It worked for me and solved my neck pain."
2012 - 2013 TESTIMONIALS
Mdm Chang Yong Fei, 61 years old (Chinese text) " My knee hurts when going down the staircase. I saw Recogen®'s advertisement in the papers and bought 2 cans of Recogen Gold and Recogen® Original. After taking 1 can, the pain subsided and symptoms improved. Now I continue taking Recogen® to maintain my health."
Mr John Boon, 73 years old, (English text), "Since taking Recogen®, I am physically fit and still able to play and teach tennis."
Mdm Kwan Yin Leng, 55 years old (Chinese text), "I used to have pain in my knee joints and feet. After trying 1 can of Recogen®, the symptoms improved."
Ms Mandy Guan for her mother, Mdm Toh Meng Hoy, 53 years old (English text), "My mum started Recogen® for about 3 months. During the first 2 weeks when she has back and joint pain. She started with Recogen® Gold, the pain worsened for a few days but when she continue with the product, it reduces. When she finished her first can, she felt a difference in the body. No more back pain and joint does not product any more "noise" when she walks. She is now on Recogen® calcium to maintain a better and healthier life! Thank you Recogen®, as it really change my mum's life!"
Mr Desmond Goh, 56 years old (Chinese text), "My colleague recommended to me Recogen®. After trying it for a while, my joint pain symptoms have improved. I've been taking for 2-3 years and have recommended to many friends since.".
Ms Chua Ser Lei, 22 years old (Chinese text) - "My grandmother has been suffering from joint pains for many years. I was recommended to Recogen® by my colleagues. I bought one and now my grandmother can walk better. My grandmother now insists on taking Recogen® every day to improve her joints condition."
Ms Ling Lee Mui, 31 years old (Chinese text) - "My mother has been complaining about her joints pain problems for many years. I was recommended to Recogen® by my colleagues and bought one for my mum to try. After finishing the first can, she happily told me that her joints were not as painful as before and she continues to take Recogen® every day. So far, she has seen big improvements in her condition!"
Ms Wong Li Shan, Melody, 33 years old (English text) - "After taking Recogen® for a month, I started to walk with less pain."
Ms Azizah, 45 years old (English text) - "I've been taking Recogen® for about a month. I think it's good since the pain in my joints around the toes and knees has reduced."
Ms Loh Seng Yoon, 55 years old (Chinese text) - "My joints, hair and scalp have shown improvements! I drink Recogen® everyday to protect my joints."
Mdm Lee Bee Sim, 56 years old (Chinese text) - "My friend recommended Recogen® to me. I have taken Recogen® for close to three month and my joint pain condition has improved alot."
Ms Chua Lay Peng, 58 years old (English text) - "I was introduced to Recogen® by a friend. We use the product for general health. The product improved my joints as well as helped with my hair growth."
Mr Arthur Allan Low, 59 years old (English text) - "I've been suffering from joint and back pain for more than 10 years since I got into an accident years ago. I've tried so many medicine and also chinese acupuncture. But they don't work for me. I was recommended by my sister's to Recogen® . I've taken Recogen® for 2 weeks and I feel so much better!"
Mr Steven Chew Kheng Moo, 61 years old (English text) - "My knees feel the pain when walking up the staircase. After taking Recogen® for about a month, my knee problem is relieved and my legs feel 'lighter'. My stiff shoulders have improved and I can move my arms much better now."
Mr Lim Kee Chong, 63 years old (English text) - "After taking 2 cans of Recogen®, I feel my joint pains have reduced. I continue to take this product to keep my joints and bones healthy."
Mr G.W. Pereira, 65 years old (English text) - "I have been taking Recogen® for the past 8 months and it improved my osteoarthritic knee.."
Mr Roslan Bin Salim, aged 47, production supervisor
" Part of my job calls for squatting for long periods of time. Due to intense pain in my kneecaps, I could not squat completely. After taking Recogen® for three weeks, the pain is reduced considerably and I am able to squat down freely without pain."
Mr Ng Tian Sing, aged 74, former truck driver
" I was about to go through an operation for severe kneecap pain but after three weeks into taking Recogen®, the pain reduced significantly and the operation not necessary. I now take Recogen® for its continued benefits."
Mdm Low Gean Gean, aged 61, retired teacher
"As a teacher, standing during classes has been the cause of pain in my knees and joints. After just 14 days on Recogen®, my knees do not hurt as bad anymore and I can enjoy my retirement."
Mr Young Kok Wee, aged 56, civil servant
" I love exercising and sports, but kneecap pains have prvented me from working out. I have been taking Recogen® for three weeks now and I am back to my old rountine...without the pain of course."
Mdm Goh Siew Kee, aged 50, draftsman
Suffering pain at the kneecap and other joints for years. After taking Recogen® pain subsides significantly and able to move and twist body freely without feeling pain as experienced before.
Ms Lim Joo Huan, aged 39
"Before using Recogen®, I always have problems with my skin. Over the years, I have tried using many brands of products - recommendations from close friends and family - none of them really worked for me. I was a little skeptical about Recogen® initially, thinking that it is "one of those products in the market". But after using it dilligently for 3 months, I noticed that my skin has gotten better. Even friends commented that I am looking more radiant and younger than ever. I am now a faithful patron of Reconge and will recommend everyone to use it."
Ms Jacqueline Goh, aged 26
"Over the years, I realized my skin was losing it's "glow". I decided to give Recogen® a try after some friends recommended it to me. I also made my DIY face mask using recogen and applied 2-3 times a week. After 2 weeks, I realized my skin was firmer and it was "glowing" from within. It also helped my joint pains which I often suffer after a round of vigorous exercise. I am still consuming Recogen® everyday for its outstanding benefits."
...and many more satisfied Recogen® customers
A: Consumption of Recogen® has no effects on weight increase or dietary imbalance. Recogen® is a protein comprising only amino acids, water and minerals and contains no fat, carbohydrates or preservatives.
Morbus Parkinson is caused by a lack of dopamine without any connection to bioactive collagen peptides. Kidney stones are made of concretions of urine. Recogen® do not contain any uretic proteins that can cause kidney stones. We advise customers who has any existing illnesses to always consult your medical doctor before starting on any types of food supplements.
Q: Which type of collagen is Recogen® made from?
A: Recogen® uses bovine hides, which contains Type 1 and Type 3 collagen (5%) which undergoes enzymatic hydrolysis to obtain Bioactive Collagen Peptides.
Q: Why is it called Bioactive Collagen Peptides?
A: It is called a Bioactive Collagen Peptide because it shows effects in our body by stimulating certain cell types like human fibroblasts, osteoblasts / osteoclasts, chondrocytes.
Q: Collagen Type I, Type II, Nano collagen, what is the difference?
A: The type of collagen plays no role when it comes to clinical effects. The difference between type I and type II collagen is negligible (< 1%), but the peptides resulting from the production process do. We describe the activity of the peptides as bioactive due to their capability of stimulating human fibroblasts, osteoblasts / osteoclasts, chondrocytes. Most products use the "types" for marketing purpose.
Q: Is it true taking hydrolyzed collagen type 2 can stimulate Type 2 collagen in joints area as claimed by some brands?
A: The collagen types are dependent on the source of raw material, chicken sternum contains type II collagen (Other Brands) and bovine hide contains type I collagen (Recogen®). Both are later treated enzymatically and broken down into peptide form.
The difference between type I and type II collagen is negligible (<1%). Once broken down into peptides, the effects highly depend on the right peptides and not if it was derived from type I and type II collagen. Potentially a hydrolyzed type II collagen could stimulate cartilage growth if it has the right composition of peptides. So far, most products claiming to contain Type II collagen do not have profound clinical data supporting them. Most products do not provide peptides that could interact with cells, therefore it is unlikely to show effects in Osteoarthritis.
Q: A product that contains undenatured collagen type 2 claims that results can be achieved with a low dosage of 40mg whereas Recogen® required 10,000mg?
A: The mode of action is different. Such products may address symptoms of Rheumatic Arthritis (RA), a defect in the immune system, Recogen®, on the other hand, contains 10,000mg (10g) of collagen peptides that are effective against the cause of Osteoarthritis (OA) which is the degeneration of cartilage tissue.
Q: Recogen is hydrolyzed collagen Type 2 or is it Type 1?
A: It is more correct to say Recogen® is obtained from Type I raw material. The type of collagen has no influence on product effectiveness. Once it's broken down to peptides (hydrolyzed), it's not possible to say if the peptides are derived from type I, II or III (also part of the collagen in skin with about 5%). Most brands use collagen types for marketing purpose. We wish to stress that the type of collagen does not affect product effectiveness. Absorption rate and bioavailability are the key factors.
Q: What is the difference between Recogen Gold’s rosehip extract versus rosehip powder?
A: Rosehip extract is not the same as rosehip powder. An extract is always more concentrated. So 0.5g or 1g rosehip extract is not the same as 5g of rosehip powder. There are no comparative studies to compare the powder and the extract, so there are no facts or figures to actually compare them. An extract's effectiveness highly depends on the extract method (whereby the right active components are retained) and raw material source.
It is also important to point out that both are different substances and so the difference in the dosage means nothing.
A: Recogen® is an excellent food supplement for the daily maintenance of your joint cartilage. For individuals who are active in what we term as "high impact" sports, the joints areas undergo severe stress and will wear out faster over time if not properly looked after. Consumption of Recogen® on a regular basis will help maintain your joint cartilage health to prevent osteoarthritis in the near future.
Osteoarthritis is a degenerative joint disease characterized by progressive destruction of joint cartilage and associated structures such as bone, synovial and fibrous joint capsule and the periarticular musculature.
Cartilage damage always arises from a disparity between the ability on the part of joint cartilage to cope with stress and the actual stress applied. There are 2 basic forms of osteoarthritis: Primary & Secondary.
Primary . Actual cause unknown. Genetic predisposition, tissue weakness, nutritional anomalies within the bradytrophic joint cartilage and other similar general factors have been considered; however a clear trigger has not yet been identified.
Secondary . Consequence of previous damage or of another illness. Such as
In USA , the number of people between the ages of 75 and 85 doubled in the two decades between 1960 and 1980; those over the age of 85 has increased by 140 %. The United States National Health and Nutrition Examination Survey (NHANES 1, 1988 - 94) found that 79 percent of men and 86 percent of women between the ages of 75 and 79 suffered from osteoarthritis of the hand.
The Framingham Study - a long-term study conducted by the National Institutes of Health in the USA since 1948 - found evidence of osteoarthritic knee conditions in one third of those studied in the age group 63-94.
Survey revealed that 6% of the adult population has significant joint or muscles aches. Most common forms of arthritis are osteoarthritis and rheumatoid arthritis, which affects about @24,000 Singaporeans. As much as 25% of people with arthritis don't do anything to relieve their symptoms.
A survey on primary medical care conducted by MOH and NUS in 2001, it was found that arthritic conditions and rheumatism are among the top 5 leading conditions for which treatment was sought in primary private and public medical care clinics in Singapore . They are accounted for 4.8% of the total attendance.
Based on National Health Surveillance Survey 2001:
Table 1: Prevalence of reported arthritis according to gender and age groups (2001)
Table 1: Prevalence of reported arthritis according to gender and age groups (2007)
In Singapore , the 1998 National Health Survey, based on the WHO criteria (normal weight: BMI 18.5-24.9; overweight: BMI 25.0-29.9; obese: BMI 30 and above) found that in adults (aged 18 to 69 years), 24.4% were overweight and 6.0% were obese; thus, 30.4% were above the normal weight. There were slightly more obese Singaporean females (6.7%) than Singaporean males (5.3%). The highest proportion of obesity was found in the 50-59 years age group.
Today, there is still no cure for osteoarthritis. At best, pain can be relieved, related inflammation suppressed and further functional impairment delayed.
Current treatments for osteoarthritis are physiotherapy,nonsteroidal anti-inflammatory drugs and local glucocorticoid crystal injections.
Surgery is only possible in certain joints and is considered a last resort because of the costs, the stress placed on the patient and the surgical risks involved.
With the growing number of patients, the progressive causes and the socio-economic impact of the disease, it is reasonable to pursue promising options in the prevention and therapy of osteoarthritis.
Taking preventive steps before the onset of irreparable degeneration is necessary. However this is difficult in cases where there are no symptoms. It also requires intensive patient motivation, counseling, and education.
Appropriate preventive measures include lifestyle changes (loss of weight, moderate physical exercise, avoidance of excessive joint strain) and the timely treatment of abnormal joint positions, infections, and other risks.
Adequate intake of certain nutrients to optimize specific metabolic processes in (blood vessel-free!) cartilaginous tissue is an additional promising approach.
Medical recommendations for preventive measures must be practical and be adopted by the patient. Unrealistic advice, e.g. drastic behavior change or time consuming and expensive therapies, is likely to fail.
Cartilage consists of cellular building blocks - the chondrocytes - and an extracellular specific matrix, which is of particular physiological significance. The extracellular matrix of the cartilage contains two classes of macromolecules: proteoglycans (such as aggrecan) which are responsible for the compressive strength and elasticity of the tissue and collagen (Type II Collagen fibrils) that provides its tensile and shear strength.
Cartilage, like bone, is subject to a continuous, slow regenerating process. There are numerous matrix metalloproteases (such as collagenase, stromelysine, aggrecanase), as well as lysosomal proteases (cathepsins), which can degrade all cartilage building blocks at neutral pH.
According to current understanding, the activity is controlled by the cytokine interleukin-1. A tissue inhibitor of metal metalloproteases and a plasminogen activator inhibitor are antagonists that inhibit the catabolic enzymes, thus slowing down cartilage degradation.
There are also polypeptide mediators, which, as growth factors, stimulate anabolic metabolic processes in cartilage, thus contributing to cartilage formation to a limited extent. This group of mediators includes the extent. This group of mediators includes the insulin-like growth factor 1 and the transforming growth factor ? both of which stimulate proteoglycan synthesis. Recent results have shown that collagen fragments such as those contained in bioactive collagen peptides can function as mediators stimulating the synthesis of cartilage matrix (Oesser et al., 2003). However, their activation requires an adequate supply of the appropriate building blocks proline and glycine.
The most frequent symptom is the pain. However, this is not an early symptom. As joint cartilage has no nerve fibers, the pains signals periarticular structure are involved.
Joint pain is generally described as a deep, dull, continuous type of pain restrictioned to a joint and its immediate environment. It occurs on movement but not at rest.
Symptoms such as:
• Brief intial pain, normally occuring after intensive or abonormal stress on the joint,
• Pain when beginning a movement ("warm-up" pain)
• Fatigue pain
• Stress pain (pain during exercise)
• Constant pain
• Night pain
• Local muscle pain (tension in muscles and tendons)
• Restricted movement
• Swollen joints
• Grinding of joints
Healthy cartilage is subject to continuous turnover as a result of anabolic and catabolic processes. For the anabolic (growth) phase, the necessary building blocks must be available in adequate quantities.
Due to the specific properties of Collagen Hydrolysate, it may be a relevant intervention in the causative process of osteoarthritis.
In addition to biochemical regulators, physical factors (e.g. physical and athletic stress) also affect cartilage metabolism. Static and continuous stress inhibit the synthesis of proteoglycans and proteins, whereas moderate stress of relatively short duration promotes the biosynthesis of matrix building blocks. While adequate amounts of physical activity and joint movement preserve cartilage, overexertion and continuous stress can give rise to pathological changes.
A patient's lifestyle plays a major role in the prevention of degenerative cartilage disease. In addition to protecting against abnormal stress, an optimal supply of the building blocks required for cartilage metabolism and tissue formation is necessary, whether in the form of food or as a nutritional supplement.
Collagen represents about 30% of mammalian protein content and has a very specific amino acid composition. The triple helical collagen molecule consists of about 1,000 glycines, 360 prolines and 300 hydroxy-prolines; the latter do not occur in any other protein. The human body can synthesise main collagen. But an enormous quanitites must be made available.
There are 21 different collage types. However Type II Collagen is the most important collagen for maintaining a healthy cartillage.
Astaxanthin is an antioxidant naturally found in krill oil extracts from krill. It is a carotenoid with scavenging ability for free radicals. Thus protecting the cell against oxidation and the damaging effects of free radicals. This antioxidant has been found to beneficial to the eye & skin health.
Serving size: 2 Soft Gels (1 Krill oil & 1 Vitamin Soft Gel)
Servings per Box: 30
Amount Per Serving
Omega 3 – Fatty acids
Vitamin D3 (cholecalciferol)
Vitamin K-2 (MK-7)
Can children take Bone K+? How much can they take?
Bone K+ is specially formulated for age 14 & above. The Omega 3 in krill oil and vitamin D and K help to support bone health.
Can I break open the soft gels and consume?
Breaking open the soft gels is never advisable.
How should I store my krill oil?
Bone K+ should be stored in a cool, dry place. Avoid direct sunlight or heat. Refrigeration is not required.
Who should take Bone K+?
Bone K+ is formulated for anyone who is age 14 & above and desires to maintain healthy bones & joints.
When is the best time to consume Bone K+?
For best absorption, consume Bone K+ once a day with a meal.
How long before I see any effects?
Results vary across individuals. We recommend daily consumption of Bone K+ for optimal bone and joint health benefits.
Can I take Bone K+ with Recogen?
Yes, you can take Bone K+ with Recogen. You will have a comprehensive bone & joint care health supplement. Bone K+ supports bone health while Recogen helps your joint cartilage.
Can I stop my fish oil after taking Bone K+?
Besides having higher EPA & DHA than fish oil, our krill oil’s unique molecular composition is rich in phospholipid (omega-3 fatty acid) and astaxanthin. When in doubt, please consult your physician.
Is there any fishy aftertaste and burps after taking Bone K+?
No. As our krill oil is a phospholipid omega-3 based oil, it dissolves in water and mixes well with stomach fluids.
How can Bone K+ supports bone health?
Bone K+ consists of Krill Oil, Vitamin D and K. Our proprietary blend aims to support & comfort bone and joints. Astaxanthin, an antioxidant naturally found our krill oil, protects the body against free radicals. Daily intake of Bone K+ can support bone health. Addition of Vitamin D & K enhances calcium absorption in building strong bones.
I am on aspirin/warfarin; can I still take Bone K+?
We highly recommend you to consult a healthcare professional prior to taking if you are taking a blood thinner medication.
I am allergic to shellfish; can I still take Bone K+?
No. We do not advise you to take Bone K+ if you are allergic to shellfish as Bone K+ contains the krill (crustacean).
Can I take Bone K+ during pregnancy & breastfeeding?
Although Bone K+ is a supplement, it has not been tested in this group. We recommend you to consult your doctor before taking any supplements.
Bones protect our internal organs from impact damage. They are living tissues that rebuild constantly throughout our life. It is estimated that we replace about 10% of skeletal bone tissue every year. In our growing years, the formation of new bones is faster than bone loss - resorption.
However, from late 30s – 40s, the rate of resorption is faster than bone formation. There’s a decrease in bone mass and density after menopause. It is necessary to build strong bones when you are young and reduce bone loss when you are older.
Joints are places that connects the bones. Together with bones, they allow body movement. Healthy bones & joints are essential for maintaining mobility in your life.
Vitamin D plays an important role in the regulation of calcium and maintenance of phosphorus levels in the blood. These two factors are crucial for maintaining healthy bones. Vitamin D absorbs calcium in the body and otherwise it will be excreted.
The current recommended daily allowance (RDA) is 600 IU for those 51-70 years of age.
Vitamin K is a fat-soluble vitamin occurs naturally in 2 forms. Vitamin K1 is found in plants; Vitamin K2 can be found in high fat dairy products, meat and fermented soy beans, natto. Unfortunately, many of the best food sources of vitamin K2 also are high in saturated fat.
Vitamin K helps to bind calcium and other important minerals to your bones.
BrainFit is a healthy supplement for kids with an exclusive blend of nutrients: Omega-3, EPA & DHA from Krill Oil and Phosphatidyl Serine (PS).
Each delicious gummy of BrainFit contains a selection of quality ingredients designed to enhance brain function for focus development and cognitive skills, the most vital of which is Phosphatidyl-Serine (PS), an essential brain-building block and key brain development compound backed by scientific research, proven to:
PET Scans at 3 levels of the brain of a 59-year-old woman with cognitive decline, treated with PS at 500 mg/day for 3 weeks.
This is normal for sugar free formula. The gummies can still be removed one by one. We recommend shaking the bottle before opening. Traditional sugar-based gummies use sugar to coat the gummies to prevent clumping, which is not healthy and suitable for a child’s dental health.
It’s suitable for children 2 years and up. Recommended dosage for children – 2 gummies per day which will provide approximately 110mg of phosphatidylserine per day.
Yes, adults may take 2-4 gummies per day
NCI uses maltitol as a sugar replacement in our gummy formula
BrainFit uses ingredients made in USA. The formula of BrainFit is conceived by NCI. The final product is produced by an established 3rd party gummy manufacturer.
Maltitol is a sugar alcohol which are found naturally in some fruits and vegetables. Maltitol is considered a carbohydrate and is a safe alternative to sugar. As the name suggests, sugar alcohol consists of both sugar and alcohol molecules. Although it’s an “alcohol”, there isn’t any ethanol, the compound that makes one drunk. Sugar alcohols are safe for children.
No, BrainFit is tooth friendly.
PS is the short form for phosphatidylserine, an active ingredient extracted from soy lecithin.
In several studies, PS is known to affect a large number of cognitive functions, among them memory, learning and attention, as well as the reduction of stress. Thus, increase in PS intake may have pronounced influence on children’s learning abilities as well as their behavior.
Yes, PS supplementation at 200mg per day (4 gummies) helps to improve ADHD symptoms.
We advise to follow the dosage instructions for best results.
Yes, our gummies are suitable for long term consumption if the dosage instructions are followed.
We use pectin to make our gummies. Pectin is a natural fruit fibre used to make the gummies.